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Northwestern University

Sonali Dhindwal, PhD

Postdoctoral researcher
Northwestern University
Chemistry of Life Processes Institute
Silverman Hall, Rm B560
2170 Campus Drive
Evanston, IL 60208-3113
Email: sonali.dhindwal@northwestern.edu


Educational/Research Background

Current Postdoctoral Fellow, Prof. Vinayak P. Dravid Lab, Northwestern University
2016-2019 Postdoctoral Fellow, Dr. Reza Khayat Lab, the City College of New York
2015-2016 Postdoctoral Fellow, Dr. Montserrat Samso Lab, Virginia Commonwealth University
2010-2014 PhD, Dr. Pravindra Kumar & Dr. Shailly Tomar Lab, Indian Institute of Technology
2007-2009 M.S. (Pharm.), National Institute of Pharmaceutical Education and Research
1998-2003 B.Pharm., Delhi Institute of Pharmaceutical Sciences and Research


Research Objectives and Approach

I am a structural biologist by training with experience in both X-ray crystallography and Cryo-Electron Microscopy. Currently, I am working on microscopy of stimuli-responsive protein based molecular structures

Publications and Supported Works

  1. Dhindwal, S., Avila B., Feng S., Khayat R. (2019) Porcine circovirus 2 uses a multitude of weak binding sites to interact with heparan sulfate, and the interactions do not follow the symmetry of the capsid. Journal of virology, 02222-18
  2. Dhindwal, S., Lobo, J., Cabra, V., Santiago, D. J., Nayak, A. R., Dryden, K., & Samsó, M. (2017). A cryo-EM–based model of phosphorylation-and FKBP12. 6-mediated allosterism of the cardiac ryanodine receptor. Science Signaling., 10(480), eaai8842.
  3. Dhindwal, S., Kesari, P., Singh H., Kumar P., Tomar S. (2016). Conformer and Pharmacophore Based Identification of Peptidomimetic Inhibitors of Chikungunya Virus nsP2 Protease, Journal of Biomolecular Structure & Dynamics, 1-43
  4. Dhindwal, S., Gomez-Gil L., Neau D., Pham. T., Sylvestre M., Eltis L., Bolin J. T., Kumar P. (2016) Structural basis of the enhanced pollutant-degrading capabilities of an engineered biphenyl dioxygenase. Journal of Bacteriology, 198.10: 1499-1512.
  5. Dhindwal S., Priyadarshini P., Patil D. N., Tapas S., Pramod K., Tomar S, Kumar P. (2015) Ligand bound structures of 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Moraxella catarrhalis reveals water channel connecting the active site for second step of catalysis. Acta Crystallographica Section D: Biological Crystallography2.
  6. Dhindwal, S., Patil, D. N., Mohammadi, M., Sylvestre, M., Tomar, S., & Kumar, P. (2011) Biochemical studies and ligand-bound structures of biphenyl dehydrogenase from Pandoraea pnomenusa strain B-356 reveal a basis for broad specificity of the enzyme. Journal of Biological Chemistry, 286(42), 37011-37022.
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