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Novel and Emerging Microscopy: Tools, Techniques & Analysis

(Supported by NSF-MRI, AFOSR, W.M. Keck Foundation, Intel, SRC, Hitachi, ANL, State of Illinois)

Research 6Microscopy has come a long way since the time of Leeuwenhoek and Hooke, who developed the early optical microscopy. With the increasing complexity of materials systems, it is essential to continue to develop microscopy techniques and analysis in the broadest sense. This includes not only real-space imaging, spectroscopy and reciprocal-space diffraction, but also localized measurements of their evolution, properties and phenomena.

We are particularly active in this area by implementing and developing a broad suite of characterization techniques based on electron, photon (light and synchrotron), ion and scanning probe techniques.

We make extensive use of the NUANCE center capabilities and develop innovative techniques for exploring the “inner” space.

We are also active in developing in-situ and ex-situ characterization techniques based on electron microscopy, diffraction, spectroscopy, as well as scanning probe and synchrotron x-ray scattering.  

Representative Publications:

  1. Gajendra S. Shekhawat, Steven M. Dudek, Vinayak P. Dravid, Development of Ultrasound Bioprobe for Biological Imaging, Science Advances, 3 (10), e1701176 (2017). DOI: 10.1126/sciadv.1701176

  2. Yue Li, Luay  M. Almassalha, John E. Chandler, Xiang Zhou, Yolanda E. Stypula-Cyrus, Karl A. Hujsak, Eric W. Roth, Reiner Bleher, Hariharan Subramanian, Igal Szleifer, Vinayak P. Dravid, Vadim Backman, The effects of chemical fixation on the cellular nanostructure. Experimental Cell Research, 358 (2), 253-259 (2017).                                              
  3. Yue Li, Di Zhang, Ilker Capoglu, Karl A. Hujsak, Dhwanil Damania, Lusik Cherkezyan, Eric Roth, Reiner Bleher, Jinsong S. Wu, Hariharan Subramanian, Vinayak P. Dravid, Vadim Backman, Measuring the Autocorrelation Function of Nanoscale Three-Dimensional Density Distribution in Individual Cells Using Scanning Transmission Electron Microscopy, Atomic Force Microscopy, and a New Deconvolution Algorithm. Microscopy and Microanalysis, 23 (3), 661-667 (2017).                                                                                                            
  4. Gajendra S. Shekhawat, Arvind K. Srivastava, Vinayak P. Dravid, Oluqaseyi Balogun, Thickness Resonance Acoustic Microscopy for Nanomechanical Sub-Surface Imaging. ACS Nano, 11 (6), 6139-6145, (2017).                                               
  5. Karl Hujsak, Benjamin D. Myers, Eric Roth, Yue Li and Vinayak P. Dravid. Suppressing Electron Exposure Artifacts: An Electron Scanning Paradigm with Bayesian Machine Learning. Microscopy and Microanalysis, 22 (4), 778-788 (2016). DOI: 10.1017/S1431927616011417.                                                                                                                                          
  6. Emily L. Que, Reiner Bleher, Francesca E. Duncan, Betty Y. Kong, Sophie C. Gleber, Stefan Vogt, Si Chen, Seth A. Garwin, Amanda R. Bayer, Vinayak P. Dravid, Teresa K. Woodruff, & Thomas V. O'Halloran. Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nature Chemistry, 7(2), 130-139 (2015).                                                        
  7. Xin Wang, Reiner Bleher, Mary E. Brown, Joe G. N. Garcia, Steven M. Dudek, Gajendra S. Shekhawat, & Vinayak P. Dravid. Nano-Biomechanical Study of Spatio-Temporal Cytoskeleton Rearrangements that Determine Subcellular Mechanical Properties and Endothelial Permeability. (2015). Scientific Reports, 5.


Links to Other Dravid Group Research Themes:

Spatially & Dimensionally Confined Structures and Assembly
Interfaces and Defect Phenomena in Advanced Materials
Synthesis, Patterning and Microscopy of Nanostructures
“Theranostic” Nanostructures: Combined Biomedical Imaging & Targeted Therapeutics
Integrated Nanosystems for Biochemical Sensing & Diagnostics
Novel Microscopy and Analysis

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