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“Theranostic” Nanostructures: Diagnostic Imaging & Targeted Therapeutics

(Supported by NIH-CCNE, NSF-MWN, NSF-INT, NMH, ENH)

Research 5

Given the similarity of size scale of nanostructures, there are exciting opportunities to interrogate and interact physical and hybrid nanostructures with biological structures, ranging from DNAs, Proteins, cells and sub-cellular organelles. Our approach is focused on synthesis of physical and hybrid nanostructures anchored by biological recognition units (e.g., antibodies) to target specific molecular and cell markers.

We use magnetic nanostructures (MNS) for contrast enhancement in magnetic resonance imaging (MRI), and targeted therapeutics facilitated by thermal activation by external RF field. Our current focus is on cancer, cardiovascular and Alzheimer’s disease (AD) via targeting the responsible cells and/or markers. We collaborate and interact with biomedicine and clinical faculty across NU campus, NTU (Singapore) as well as local area hospitals (ENH, NMH,CMRC) for advancing medicine through materials research. Here are some projects currently going on in the lab.

Representative Publications:

  1. Vikas Nandwana, Ruiying Zhou, Jeotikanta Mohapatra, Pottumarthi V. Prasad, J. Ping Liu, Vinayak P. Dravid. Exchange coupling in soft magnetic nanostructures and its impact of their theranostic properties. ACS Applied Materials & Interfaces (submitted).
  2. ​Vikas Nandwana, Wenyuan Huang, Yuan Li, Vinayak P. Dravid, V. P. (2018). One-Pot Green Synthesis of Fe3O4/MoS2 0D/2D Nanocomposites and Their Application in Noninvasive Point-of-Care Glucose Diagnostics. ACS Applied Nano Materials, 1(4), 1949-1958 (2018). DOI:10.1021/acsanm.8b00429.
  3. Vikas Nandwana,  Abhalaxmi Singh,  Marisa M. You,  Gefei Zhang,  John Higham,  Tiffany Zheng,  Yue Li,  Pottumarthi V. Prasad  and  Vinayak Dravid. Magnetic lipid nanocapsules (MLNCs): Self-assembled lipid based nanoconstruct for non-invasive theranostic applications. Journal of Materials Chemistry B, 6, 1026-1034 (2018). DOI: 10.1039/C7TB03160B, 2018 
  4. Vikas Nandwana, Soo-Ryoon Ryoo, Shanthi Kanthala,  A. Kumar,  Ajay Sharma, Fernando C. Castro, Yue Li, Brian Hoffman, Sierin Lim  and  Vinayak P. Dravid. Engineered ferritin nanocages as natural contrast agents in magnetic resonance imaging, RSC Advances, 7, 34892-34900​ (2017). DOI: 10.1039/C7RA05681H 
  5. Vikas Nandwana, Soo-Ryoon Ryoo, Shanthi Kanthala, Kaylin M. McMahon, Jonathan S. Rink, Yue Li, Subbu S. Venkatraman, C. Shad Thaxton, Vinayak P. Dravid High-Density Lipoprotein-like Magnetic Nanostructures (HDL-MNS): Theranostic Agents for Cardiovascular Disease, Chemistry of Materials, 29(5), 2276-2282, (2017). ​DOI: 10.1021/acs.chemmater.6b05357
  6. Vikas Nandwana, Soo-Ryoon Ryoo, Shanthi Kanthala, Mrinmoy De, Stanley S Chou, Pottumarthi V. Prasad, & Vinayak P. Dravid Engineered theranostic magnetic nanostructures: Role of composition and surface coating on magnetic resonance imaging contrast and thermal activation. ACS Applied Materials & Interfaces, 8(11), 6953-6961 (2016). DOI: 10.1021/acsami.6b01377​
  7. Vikas Nandwana, Mrinmoy De, Shihyao Chu, Manish Jaiswal, Matt Rotz, Thomas J. Meade, & Vinayak P. Dravid. Theranostic Magnetic Nanostructures (MNS) for Cancer. Cancer Treatment and Research, 166, 51-83 (2015). DOI:10.1007/978-3-319-16555-4_3.
  8. Manish K. Jaiswal, Lina Pradhan, Shaleen Vasavada, Mrinmoy De, H. D. Sarma, Anand Prakash, D. Bahadur, Vinayak P. Dravid, Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution. Colloids and surfaces B Biointerfaces, 136, 625-633 (2015). DOI: 10.1016/j.colsurfb.2015.09.058.
  9. Kirsten L. Viola, James Sbarboro, Ruchi Sureka, Mrinmoy De, Mara A. Bicca, Jane Wang, Shaleen Vasavada, Sreyesh Satpathy, Summer Wu, Hrushikesh Joshi, Pauline T. Velasco, Keith MacRenaris, E. Alex Waters, Chang Lu, Joseph Phan, Pascale Lacor, Pottumarthi Prasad, Vinayak P. Dravid, & William L. Klein. Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nature Nanotechnology, 10(1), 91-98 (2015). DOI:10.1038/nnano.2014.254.
  10. Manish K. Jaiswal, Mrinmoy De, Stanley S. Chou, Shaleen Vasavada, Reiner Bleher, Pottumarthi V. Prasad, Dhirendra Bahadur, Vinayak P. Dravid, Thermoresponsive magnetic hydrogels as theranostic nanoconstructs. ACS Applied Materials & Interfaces 6, 6237-6247 (2014). DOI: 10.1021/am501067j.

 

Links to Other Dravid Group Research Themes:

Spatially & Dimensionally Confined Structures and Assembly
Interfaces and Defect Phenomena in Advanced Materials
Synthesis, Patterning and Microscopy of Nanostructures
“Theranostic” Nanostructures: Combined Biomedical Imaging & Targeted Therapeutics
Integrated Nanosystems for Biochemical Sensing & Diagnostics
Novel Microscopy and Analysis

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