Integrated Nanosystems for Bio-Chem Sensing & Diagnostics
(Supported by NSF-ECS, NSF-INT, DARPA, Baxter, SRC, CMRC, NMH)
We are developing a multi-modal (sensor fusion) framework, anchored by the microcantilever sensor platform. Our focus is on integration of the microcantilever sensor system with sampling and concentrators on the back-end and networking and signal integration on the front end. The former will focus on fluidic sampling covering “non-invasive” substrates such as saliva, sweat and breath; with a potential for a small and portable sensing and diagnostics system. Further, the innate device multiplication in microfabrication allows to us build-in redundancy for each sensor element, thereby increasing selectivity and specificity by requiring redundant/duplicate sensor elements to behave within a narrow range of each other.
The integrated cantilever system is built with an integrated sensor network, which incorporates engineering innovation of system-level integration, with modules for sampling and concentrators, all-electronic readout and RF network unit. The integrated and collective developments will provide for potentially “turn-key” equipment that would serve as an integrated platform and will have three major functional sub-systems: (a) The sampling and concentrators – for fluidic flow (sweat, blood, solution and breath/air/gas), (b) MOSFET (Metal oxide semiconductor field effect transistor)-based sensor and readout module – where signal transduction and detection is performed; and (c) RF (radio frequency) platform –for signal integration, amplification and networking.
- Shekhawat, G. S., Dravid, V. P., Biosensors: Microcantilevers to Lift Biomolecules. Nat Nano (2015), 10 (10), pp 830.
- Chou, S. S., Kaehr, B., Kim, J., Foley, B. M., De, M., Hopkins, P. E., Huang, J. X., Dravid, V. P., “Chemically Exfoliated MoS2 as Near-Infrared Photothermal Agents”, Angewandte Chemie-International Edition, 52(15), 4160-4164, (2013).
- Late, D. J., Huang, Y. K., Liu, B., Acharya, J., Shirodkar, S. N., Luo, J., Yan, A., Charles, D., Waghmare, U. V., Dravid, V. P., Rao, C. N., “Sensing Behavior of Atomically Thin-Layered MoS Transistors”, ACS Nano, (2013).
- Sharma, P., Tuteja, S. K., Bhalla, V., Shekhawat, G., Dravid, V. P., & Suri, C. R. “Bio-functionalized Graphene-graphene Oxide Nanocomposite Based Electrochemical Immunosensing”, Biosensors & Bioelectronics, 39(1), 99-105, (2013).
- Shekhawat, G. S., & Dravid, V. P., “Nanomechanical sensors: Bent on detecting cancer”, Nature Nanotechnology, 8(2), 77-78, (2013).
- Tae Hee Han, Yi-Kai Huang, Alvin T. L. Tan, Vinayak P. Dravid, and Jiaxing Huang, Steam Etched Porous Graphene Oxide Network for Chemical Sensing, J. Am. Chem. Soc., 2011, 133 (39), 15264–15267.
Links to Other Dravid Group Research Themes:
Spatially & Dimensionally Confined Structures and Assembly
Interfaces and Defect Phenomena in Advanced Materials
Synthesis, Patterning and Microscopy of Nanostructures
“Theranostic” Nanostructures: Combined Biomedical Imaging & Targeted Therapeutics
Integrated Nanosystems for Biochemical Sensing & Diagnostics
Novel Microscopy and Analysis