Northwestern University
Ph.D. Candidate, Materials Sci. & Eng.
Evanston, IL
1999-2003
State University of New York at Stony Brook
B.S. Materials Sci. & Eng.
Stony Brook, NY
Research Objective(s) and Approach
Fundamental/quantitative validation of the new electronic signal transduction and detection paradigm based on the MOSFET-embedded microcantilevers
Simulation and experimental studies to improve and optimize sensor platform performance
Evaluation of sensitivity, selectivity, and reproducibility of the MOSFET cantilever sensor platform with biomolecular and chemical detection experiments
Cross-validation of MOSFET-embedded cantilever sensing performance with conventional optical deflection detection approach
Optimization and application of novel receptors and their immobilization strategies for biological and chemical detection on microcantilevers
Results
New electronic, label- and optics-free signal transduction based on MOSFET-embedded cantilevers allows real-time detection of biomolecular interactions with high sensitivity and selectivity by simple direct current measurement as demonstrated in the following results.
Future directions
Design and fabrication of integrated microfluidic system
Differential output signal analysis using integrated CMOS
Functionalization of cantilever arrays for multi-target detection
Remote addressability via integrated radio frequency elements
Nanotech News, National Cancer Institute (Feb 27, 2006)
CenterPiece, Office for Research, Northwestern University (Spring 2006)
References
Lavrik, N. V.; Sepaniak, M. J.; Datskos, P. G., Cantilever transducers as a platform for chemical and biological sensors. Review Of Scientific Instruments 2004, 75, (7), 2229-2253.
Hansen, K. M.; Thundat, T., Microcantilever biosensors. Methods 2005, 37, (1), 57-64.
Group Leader
