Saurabh Sharma, Ph.D.
Materials Science and Engineering
Room: B560, Silverman Hall
Chemistry of Life Processes Institute,
2170 Campus Drive, Evanston IL, 60208-3113
Phone: (847) 467-2651
Facsimile: (847) 491-7280
Despite substantial progress in the treatment of cancer, it remains the second leading cause of death in the United States and is expected to become the leading cause of death within the next decade. The prevalence and gravity of the disorder, its refractoriness to current approaches, and the toxicity and disabilities caused by current therapies suggest that fundamentally new approaches must be developed. We envision development, characterization and preclinical validation of magnetic nanostructures (MNS) based "smart" nanoplatforms that will selectively accumulate and aggregate within tumors in vivo. Once accumulation occurs, ideally the imaging or therapeutic contrast should scale more than linearly with the number of assembled MNS. Our hit-to-lead efforts is to demonstrate such theranostic contrast for simultaneous magnetic resonance imaging T2 relaxivity and hysteresis-induced thermal activation therapy due to iron oxide core. We are developing new approaches to engineer functionalize MNS to accumulate preferentially within tumors rather than in normal tissue.
- S. Ichi, F. Costa, J. Bischof, H. Nakazaki, Y.W. Shen, V. Boshnjaku, Saurabh Sharma, B. M. Farnell, D. McLone, T. Tomita, M. Soares, C.S. Mayanil, “Epigenetic changes by folic acid during murine caudal neural tube development” Journal of Biological Chemistry 285(47), 36922-36932 2010
- J.S. Wu, Lambert, M.P., Velasco,P.T., Gutiontov,S., Joshi, H.M., Saurabh Sharma, Shekhawat, G., Klein, W.L., and Dravid, V.P. “Oligomeric and fibrillar amyloid-beta42 studied by cryo TEM”. Microscopy and Microanalysis 15 (SUPPL.2), 944-945 2009.
- G. Shekhawat, M. Lambert, Saurabh Sharma, B Klein and V.P. Dravid, “Soluble State High Resolution Atomic Force Microscopy Study of Alzheimer’s b-amyloid Oligomers” Applied Physics Letters 94, 183701 2009.
- Y. Nangia, N. Wangoo, Saurabh Sharma, V. P. Dravid, G. Shekhawat, and C. Suri, “Facile Biosynthesis of Phosphate Capped Gold Nanoparticles by a Bacterial Isolate Stenotrophomonas maltophilia.” Applied Physics Letters 94, 233901 2009
J.S. Wu, Lambert, M.P., Velasco,P.T., Gutiontov,S.,Saurabh Sharma,Joshi, H.M., Shekhawat, G., Klein, W.L., and Dravid, V.P. “Oligomeric and fibrillar amyloid-beta42 studied by cryo TEM”. Microscopy and Microanalysis< 15 (SUPPL.2), 944-945 2009.